Semax is a high-purity synthetic heptapeptide developed as a structurally stable analog of a fragment of adrenocorticotropic hormone (\bm{ACTH_{4-10}}). By fusing a prolyl-glycyl-proline (PGP) tripeptide sequence to the C-terminus of the core ACTH fragment (Met-Glu-His-Phe), the molecule is uniquely protected against rapid enzymatic breakdown, drastically extending its structural stability in cellular environments.

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